Details

Autor(en) / Beteiligte

• Shao, Xinrui
• Chen, Siyuan
• Yang, Daping
• Cao, Mengtao
• Yao, Yikun
• Wu, Zhengxi
• Li, Ningli
• Shen, Nan
• Li, Xiaoxia
• Song, Xinyang
• Qian, Youcun

Titel

FGF2 cooperates with IL-17 to promote autoimmune inflammation

Ist Teil von

• Scientific reports, 2017-08, Vol.7 (1), p.7024-7024, Article 7024

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2017

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• IL-17 is a pro-inflammatory cytokine implicated a variety of autoimmune diseases. We have recently reported that FGF2 cooperates with IL-17 to protect intestinal epithelium during dextran sodium sulfate (DSS)-induced colitis. Here, we report a pathogenic role of the FGF2-IL-17 cooperation in the pathogenesis of autoimmune arthritis. Combined treatment with FGF2 and IL-17 synergistically induced ERK activation as well as the production of cytokines and chemokines in human synovial intimal resident fibroblast-like synoviocytes (FLS). Furthermore, ectopic expression of FGF2 in mouse joints potentiated IL-17-induced inflammatory cytokine and chemokine production in the tissue. In the collagen-induced arthritis (CIA) model, while ectopic expression of FGF2 in vivo exacerbated tissue inflammation and disease symptom in the wild-type controls, the effect was largely blunted in Il17a −/− mice. Taken together, our study suggests that FGF2 cooperates with IL-17 to promote the pathogenesis of autoimmune arthritis by cooperating with IL-17 to induce inflammatory response.