Details

Autor(en) / Beteiligte

• Yu, Bo
• Lang, Xiaoxue
• Wang, Xiangtao
• Ding, Lijuan
• Han, Meihua
• Guo, Yifei
• Dong, Zhengqi

Titel

Effects of different conformations of polylysine on the anti-tumor efficacy of methotrexate nanoparticles

Ist Teil von

• Biomedicine & pharmacotherapy, 2023-06, Vol.162, p.114662-114662, Article 114662

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Drug delivery systems require that carrier materials have good biocompatibility, degradability, and constructability. Poly(amino acids), a substance with a distinctive secondary structure, not only have the basic features of the carrier materials but also have several reactive functional groups in the side chain, which can be employed as drug carriers to deliver anticancer drugs. The conformation of isomers of drug carriers has some influence on the preparation, morphology, and efficacy of nanoparticles. In this study, two isomers of polylysine, including ε-polylysine (ε-PL) and α-polylysine (α-PL), were used as drug carriers to entrap methotrexate (MTX) and construct nano-drug delivery systems. ε-PL/MTX nanoparticles with the morphology of helical nanorods presented a small particle size (115.0 nm), and relative high drug loading content (57.8 %). The anticancer effect of ε-PL/MTX nanoparticles was 1.3-fold and 2.6-fold stronger than that of α-PL/MTX nanoparticles in vivo and in vitro, respectively. ε-PL is an ideal drug carrier with potential clinical application prospects. [Display omitted] •ε-Polylysine is produced by microorganisms with good biosafety, easy to obtain and low price.•The monohydrophilic carrier encapsulate hydrophobic drugs with high drug-loading content via electrostatic interaction. The monohydrophilic carrier combines hydrophobic drugs through electrostatic interaction and can achieve high drug loading.•ε-PL/MTX NPs exhibit helical rod-like morphology and present better antitumor efficacy in vitro and in vivo.