Details

Autor(en) / Beteiligte

• Bonheur, Ashley N
• Thomas, Sarah
• Soshnick, Sara H
• McGibbon, Emily
• Dupuis, Alan P
• Hull, Rene
• Slavinski, Sally
• Del Rosso, Paula E
• Weiss, Don
• Hunt, Danielle T
• McCabe, Megan E
• Dean, Amy B
• Folkerth, Rebecca
• Laib, Anne M
• Wong, Susan J

Titel

A fatal case report of antibody-dependent enhancement of dengue virus type 1 following remote Zika virus infection

Ist Teil von

• BMC infectious diseases, 2021-08, Vol.21 (1), p.1-749, Article 749

Ort / Verlag

London: BioMed Central Ltd

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Springer Nature - Complete Springer Journals

Beschreibungen/Notizen

• Dengue virus (DENV) is endemic in many parts of the world. Antibody dependent enhancement (ADE) in DENV infections occurs when a person with primary immunity is infected by a second, different DENV strain. Antibodies to Zika virus (ZIKV), which emerged in the Western Hemisphere in 2015, are cross reactive with DENV and theoretically could provoke ADE in a DENV naïve individual. We report the first known patient in the United States with a rapidly progressive and fatal case of travel-associated DENV in which prior exposure to ZIKV likely played a role in triggering an ADE phenomenon. This association of prior ZIKV immunity and subsequent new dengue infection is a worrisome phenomenon and an important contribution to the body of knowledge on immunity to flaviviruses.