Details

Autor(en) / Beteiligte

• Van Nguyen, Dung
• Van Nguyen, Cuong
• Bonsall, David
• Ngo, Tue Tri
• Carrique-Mas, Juan
• Pham, Anh Hong
• Bryant, Juliet E
• Thwaites, Guy
• Baker, Stephen
• Woolhouse, Mark
• Simmonds, Peter

Titel

Detection and Characterization of Homologues of Human Hepatitis Viruses and Pegiviruses in Rodents and Bats in Vietnam

Ist Teil von

• Viruses, 2018-02, Vol.10 (3), p.102

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2018

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat species, including their origins, evolution, and range of hosts. In this study of pegivirus and human hepatitis-related viruses, liver and serum samples from Vietnamese rodents and bats were examined by PCR and sequencing. Nucleic acids homologous to human hepatitis B, C, E viruses were detected in liver samples of 2 (1.3%) of 157 bats, 38 (8.1%), and 14 (3%) of 470 rodents, respectively. Hepacivirus-like viruses were frequently detected (42.7%) in the bamboo rat, , while pegivirus RNA was only evident in 2 (0.3%) of 638 rodent serum samples. Complete or near-complete genome sequences of HBV, HEV and pegivirus homologues closely resembled those previously reported from rodents and bats. However, complete coding region sequences of the rodent hepacivirus-like viruses substantially diverged from all of the currently classified variants and potentially represent a new species in the genus. Of the viruses identified, their routes of transmission and potential to establish zoonoses remain to be determined.