Details

Autor(en) / Beteiligte

• Henry, Noëlie Béré
• Sermé, Samuel Sindié
• Siciliano, Giulia
• Sombié, Salif
• Diarra, Amidou
• Sagnon, N'fale
• Traoré, Alfred S
• Sirima, Sodiomon Bienvenu
• Soulama, Issiaka
• Alano, Pietro

Titel

Biology of Plasmodium falciparum gametocyte sex ratio and implications in malaria parasite transmission

Ist Teil von

• Malaria journal, 2019-03, Vol.18 (1), p.70-70, Article 70

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2019

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• While significant advances have been made in understanding Plasmodium falciparum gametocyte biology and its relationship with malaria parasite transmission, the gametocyte sex ratio contribution to this process still remains a relevant research question. The present review discusses the biology of sex determination in P. falciparum, the underlying host and parasite factors, the sex specific susceptibility to drugs, the effect of sex ratio dynamics on malaria parasite transmission and the development of gametocyte sex specific diagnosis tools. Despite the inherent differences across several studies and approaches, the emerging picture highlights a potentially relevant contribution of the P. falciparum gametocyte sex ratio in the modulation of malaria parasite transmission. The increasing availability of molecular methods to measure gametocyte sex ratio will enable evaluation of important parameters, such as the impact of drug treatment on gametocyte sex ratio in vitro and in vivo as well as the changes of gametocyte sex ratios in natural infections, key steps towards elucidating how these parameters affect parasite infectiousness to the mosquito vectors.