Nutrients, 2023-06, Vol.15 (13), p.2928
2023
Details
- Autor(en) / Beteiligte
- Titel
- Bean Leaves Ameliorate Lipotoxicity in Fatty Liver Disease
- Ist Teil von
- Nutrients, 2023-06, Vol.15 (13), p.2928
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2023
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Bioactive compounds in plant-based food have protective effects against metabolic alterations, including non-alcoholic fatty liver disease (NAFLD). Bean leaves are widely cultivated in the world and are a source of dietary fiber and polyphenols. High fat/high fructose diet animal models promote deleterious effects in adipose and non-adipose tissues (lipotoxicity), leading to obesity and its comorbidities. Short-term supplementation of bean leaves exhibited anti-diabetic, anti-hyperlipidemic, and anti-obesity effects in high-fat/high-fructose diet animal models. This study aimed to evaluate the effect of bean leaves supplementation in the prevention of lipotoxicity in NAFLD and contribute to elucidating the possible mechanism involved for a longer period of time. During thirteen weeks, male Wistar rats ( = 9/group) were fed with: (1) S: Rodent Laboratory Chow 5001 (RLC); (2) SBL: 90% RLC+ 10% dry bean leaves; (3) H: high-fat/high-fructose diet; (4) HBL: H+ 10% of dry bean leaves. Overall, a HBL diet enhanced impaired glucose tolerance and ameliorated obesity, risk factors in NAFLD development. Additionally, bean leaves exerted antioxidant (↑serum GSH) and anti-inflammatory (↓mRNA TNFα in the liver) effects, prevented hepatic fat accumulation by enhanced ↑mRNA PPARα (β oxidation), and enhanced lipid peroxidation (↓liver MDA). These findings suggest that bean leaves ameliorated hepatic lipotoxicity derived from the consumption of a deleterious diet.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2072-6643eISSN: 2072-6643DOI: 10.3390/nu15132928Titel-ID: cdi_doaj_primary_oai_doaj_org_article_7178977382bb4e69919c72bc83a938bb
- Format
- –
- Schlagworte
- Adipose tissue, Animal models, Animals, Antioxidants, bean leaves, Beans, Bioactive compounds, Cholesterol, Comorbidity, Diabetes mellitus, Diet, Diet, High-Fat - adverse effects, dietary fiber, Fatty acids, Fatty liver, Fructose, Fructose - metabolism, Glucose, Glucose tolerance, High density lipoprotein, High fat diet, Homeostasis, Humans, Inflammation, Insulin resistance, Laboratories, Leaves, Legumes, Lipid peroxidation, Lipids, Lipoproteins, lipotoxicity, Liver, Liver - metabolism, Liver diseases, MAFLD, Magnetic resonance imaging, Male, Metabolism, Mimosaceae, mRNA, Non-alcoholic Fatty Liver Disease - etiology, Obesity, Obesity - metabolism, Oxidation, Oxidative stress, Peroxidation, Plant Leaves - metabolism, Plant-based foods, Polyphenols, Proteins, Rats, Rats, Wistar, Risk factors, RNA, Triglycerides, Vegetables