Details

Autor(en) / Beteiligte

• Fedorova, Evgenia N.
• Egorova, Anna V.
• Voronkov, Dmitry N.
• Mudzhiri, Natalia M.
• Baranich, Tatiana I.
• Glinkina, Valeria V.
• Krapivkin, Alexey I.
• Mamedov, Ilgar S.
• Sukhorukov, Vladimir S.

Titel

DRP1 Regulation as a Potential Target in Hypoxia-Induced Cerebral Pathology

Ist Teil von

• Journal of Molecular Pathology, 2023-12, Vol.4 (4), p.333-348

Ort / Verlag

Basel: MDPI AG

Erscheinungsjahr

2023

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The following review considers current concepts concerning the characteristics of DRP1-related mitochondrial division in brain cells during hypoxic-ischemic pathology. The functional role of DRP1 in neurons and astroglia in cerebral ischemia conditions was analyzed. We discuss the potential for regulating DRP1 activity through the selective inhibitor of mitochondrial fission, mdivi-1. The article also presents data on DRP1 involvement in astro- and microglia-mediated intercellular mitochondrial transport. Understanding of the molecular mechanisms responsible for mitochondrial fission during hypoxic-ischemic exposure will allow us to consider DRP1 as an effective therapeutic target for treating conditions with a hypoxic component.