Details

Autor(en) / Beteiligte

• Fusayasu, Naoko
• Asaumi, Tomoyuki
• Takahashi, Kyohei
• Nagakura, Ken-ichi
• Nishino, Makoto
• Sato, Sakura
• Yanagida, Noriyuki
• Ebisawa, Motohiro

Titel

History of immediate reactions changes the predictive accuracy for pediatric peanut allergy

Ist Teil von

• Allergology International, 2022-04, Vol.71 (2), p.248-250

Ort / Verlag

England: Elsevier B.V

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Dear Editor, Peanut is the causative agent in 5.1% of all food allergy cases in Japan. Although an oral food challenge (OFC) is the gold standard to diagnose peanut allergy, severe reactions occasionally occur during an OFC. A specific immunoglobulin E (sIgE) level against Arachis hypogaea (Ara h) 2 could be a biomarker for diagnosing peanut allergy. However, values differ between studies because sIgE level depends on the patient's background. Peters et al. showed that a history of reactions to peanuts altered the 95% predictive decision point (PPV) of peanut sIgE for peanut allergy; however, there has been no reported evaluation of the influence of a history of immediate reactions on the PPV of Ara h 2 sIgE and 5% PPV of peanut sIgE. Here, we evaluated these in children. In this study, we analyzed data from participants aged <18 years who underwent a 3-g peanut (750-mg peanut protein) OFC on admission from March 2010 to March 2016 at Sagamihara National Hospital (Supplementary Methods). Overall, 128 patients (median age: 6.7 years) were assessed (Supplementary Results, Supplementary Fig.1, and Supplementary Table 1).