Details

Autor(en) / Beteiligte

• Damjanovic, Jonathan
• Janssen, Jan-Carlo
• Prasad, Vikas
• Diederichs, Gerd
• Walter, Thula
• Brenner, Winfried
• Makowski, Marcus R

Titel

68Ga-PSMA-PET/CT for the evaluation of liver metastases in patients with prostate cancer

Ist Teil von

• Cancer imaging, 2019-06, Vol.19 (1), p.37-37, Article 37

Ort / Verlag

London: BioMed Central Ltd

Erscheinungsjahr

2019

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• Background The purpose of this study was to evaluate the imaging properties of hepatic metastases in .sup.68Ga-PSMA positron emission tomography (PET) in patients with prostate cancer (PC). Methods .sup.68Ga-PSMA-PET/CT scans of PC patients available in our database were evaluated retrospectively for liver metastases. Metastases were identified using .sup.68Ga-PSMA-PET, CT, MRI and follow-up scans. Different parameters including, maximum standardized uptake values (SUV.sub.max) of the healthy liver and liver metastases were assessed by two- and three-dimensional regions of interest (2D/3D ROI). Results One hundred three liver metastases in 18 of 739 PC patients were identified. In total, 80 PSMA-positive (77.7%) and 23 PSMA-negative (22.3%) metastases were identified. The mean SUV.sub.max of PSMA-positive liver metastases was significantly higher than that of the normal liver tissue in both 2D and 3D ROI (p [less than or equai to] 0.05). The mean SUV.sub.max of PSMA-positive metastases was 9.84 [+ or -] 4.94 in 2D ROI and 10.27 [+ or -] 5.28 in 3D ROI; the mean SUV.sub.max of PSMA-negative metastases was 3.25 [+ or -] 1.81 in 2D ROI and 3.40 [+ or -] 1.78 in 3D ROI, and significantly lower than that of the normal liver tissue (p [less than or equai to] 0.05). A significant (p [less than or equai to] 0.05) correlation between SUV.sub.max in PSMA-positive liver metastases and both size ([rho].sub.Spearman = 0.57) of metastases and PSA serum level ([rho].sub.Spearman = 0.60) was found. Conclusions In .sup.68Ga-PSMA-PET, the majority of liver metastases highly overexpress PSMA and is therefore directly detectable. For the analysis of PET images, it has to be taken into account that also a significant portion of metastases can only be detected indirectly, as these metastases are PSMA-negative. Keywords: Liver metastasis, PSMA, PET/CT, Prostate cancer