Details

Autor(en) / Beteiligte

• Torii, Hidemasa
• Kurihara, Toshihide
• Seko, Yuko
• Negishi, Kazuno
• Ohnuma, Kazuhiko
• Inaba, Takaaki
• Kawashima, Motoko
• Jiang, Xiaoyan
• Kondo, Shinichiro
• Miyauchi, Maki
• Miwa, Yukihiro
• Katada, Yusaku
• Mori, Kiwako
• Kato, Keiichi
• Tsubota, Kinya
• Goto, Hiroshi
• Oda, Mayumi
• Hatori, Megumi
• Tsubota, Kazuo

Titel

Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression

Ist Teil von

• EBioMedicine, 2017-02, Vol.15 (C), p.210-219

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Prevalence of myopia is increasing worldwide. Outdoor activity is one of the most important environmental factors for myopia control. Here we show that violet light (VL, 360–400nm wavelength) suppresses myopia progression. First, we confirmed that VL suppressed the axial length (AL) elongation in the chick myopia model. Expression microarray analyses revealed that myopia suppressive gene EGR1 was upregulated by VL exposure. VL exposure induced significantly higher upregulation of EGR1 in chick chorioretinal tissues than blue light under the same conditions. Next, we conducted clinical research retrospectively to compare the AL elongation among myopic children who wore eyeglasses (VL blocked) and two types of contact lenses (partially VL blocked and VL transmitting). The data showed the VL transmitting contact lenses suppressed myopia progression most. These results suggest that VL is one of the important outdoor environmental factors for myopia control. Since VL is apt to be excluded from our modern society due to the excessive UV protection, VL exposure can be a preventive strategy against myopia progression. •Violet light (360–400nm wavelengths) suppressed the axial length elongation both in a chick myopia model and in human.•The myopia suppressive gene EGR1 was upregulated by the violet light exposure.•Violet light, one of the myopia suppressive factors in the outdoor environment, is deficient from our modern society. Short-sightedness (myopia) has been increasing worldwide especially over the past 50years. Our studies on chicks and humans revealed that violet light (360–400nm wavelength) suppressed myopia progression. At a molecular level we found that violet light increased the expression of the gene EGR1 known to prevent myopia. Interestingly, violet light is deficient in our modern society because various ultraviolet-protected products are not transmitting violet light, and light sources such as LED irradiate no violet light. Ultraviolet protection is important for ocular health, but excessive ultraviolet protection, including violet light, should be reconsidered from the aspect of myopia control.