Molecules (Basel, Switzerland), 2021-03, Vol.26 (5), p.1424
2021
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- Autor(en) / Beteiligte
- Titel
- Radiofrequency Irradiation Modulates TRPV1-Related Burning Sensation in Rosacea
- Ist Teil von
- Molecules (Basel, Switzerland), 2021-03, Vol.26 (5), p.1424
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Rosacea is a skin inflammatory condition that is accompanied by not only redness and flushing but also unseen symptoms, such as burning, stinging, and itching. TRPV1 expression in UVB-exposed skin can lead to a painful burning sensation. Upregulated TRPV1 expression helps release neuropeptides, including calcitonin gene-related peptide, pituitary adenylate cyclase-activating polypeptide, and vasoactive intestinal peptide, which can activate macrophage and inflammatory molecules. In this study, we found that radiofrequency (RF) irradiation reduced TRPV1 activation and neuropeptide expression in a UVB-exposed in vivo model and UVB- or heat-treated in an in vitro model. RF irradiation attenuated neuropeptide-induced macrophage activation and inflammatory molecule expression. Interestingly, the burning sensation in the skin of UVB-exposed mice and patients with rosacea was significantly decreased by RF irradiation. These results can provide experimental and molecular evidence on the effective use of RF irradiation for the burning sensation in patients with rosacea.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1420-3049eISSN: 1420-3049DOI: 10.3390/molecules26051424Titel-ID: cdi_doaj_primary_oai_doaj_org_article_70fb81bfe7a1454e8cc70e34f75e1b5e
- Format
- –
- Schlagworte
- Angiogenesis, Animals, Burning, burning sensation, Calcitonin, Calcitonin gene-related peptide, Capsaicin receptors, Cell activation, Cell adhesion & migration, Exposure, Heat, Heat treatment, Hyperthermia, Induced - methods, Inflammation, Inflammation - chemically induced, Inflammation - metabolism, Inflammation - pathology, Inflammation - prevention & control, Intestine, Irradiation, Itching, Kinases, Macrophages, Male, Mice, microneedling radiofrequency, Neuropeptides, Neuropeptides - toxicity, Pain, Pain - etiology, Pain - metabolism, Pain - pathology, Pain - prevention & control, Peptides, Pituitary adenylate cyclase-activating polypeptide, Polypeptides, Proteins, Radiation, Radio frequency, Rosacea, Rosacea - complications, Skin, Skin - metabolism, Skin - pathology, Skin - radiation effects, TRPV Cation Channels - genetics, TRPV Cation Channels - metabolism, TRPV1, Ultraviolet Therapy - methods, Vasoactive agents, Vasoactive intestinal peptide