Details

Autor(en) / Beteiligte

• Jiang, Xianjie
• Wang, Jie
• Deng, Xiangying
• Xiong, Fang
• Ge, Junshang
• Xiang, Bo
• Wu, Xu
• Ma, Jian
• Zhou, Ming
• Li, Xiaoling
• Li, Yong
• Li, Guiyuan
• Xiong, Wei
• Guo, Can
• Zeng, Zhaoyang

Titel

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

Ist Teil von

• Molecular cancer, 2019-01, Vol.18 (1), p.10-17, Article 10

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Tumor immune escape is an important strategy of tumor survival. There are many mechanisms of tumor immune escape, including immunosuppression, which has become a research hotspot in recent years. The programmed death ligand-1/programmed death-1 (PD-L1/PD-1) signaling pathway is an important component of tumor immunosuppression, which can inhibit the activation of T lymphocytes and enhance the immune tolerance of tumor cells, thereby achieving tumor immune escape. Therefore, targeting the PD-L1/PD-1 pathway is an attractive strategy for cancer treatment; however, the therapeutic effectiveness of PD-L1/PD-1 remains poor. This situation requires gaining a deeper understanding of the complex and varied molecular mechanisms and factors driving the expression and activation of the PD-L1/PD-1 signaling pathway. In this review, we summarize the regulation mechanisms of the PD-L1/PD-1 signaling pathway in the tumor microenvironment and their roles in mediating tumor escape. Overall, the evidence accumulated to date suggests that induction of PD-L1 by inflammatory factors in the tumor microenvironment may be one of the most important factors affecting the therapeutic efficiency of PD-L1/PD-1 blocking.