Details

Autor(en) / Beteiligte

• Sun, Zi-Min
• Liu, Hui-Lan
• Geng, Liang-Quan
• Wang, Xin-Bing
• Yao, Wen
• Liu, Xin
• Ding, Kai-Yang
• Han, Yong-Sheng
• Yang, Hui-Zhi
• Tang, Bo-lin
• Tong, Juan
• Zhu, Wei-Bo
• Wang, Zu-Yi

Titel

HLA-matched sibling transplantation with G-CSF mobilized PBSCs and BM decreases GVHD in adult patients with severe aplastic anemia

Ist Teil von

• Journal of hematology and oncology, 2010-12, Vol.3 (1), p.51-51, Article 51

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2010

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for severe aplastic anemia (SAA). However, graft failure and graft-versus-host disease (GVHD) are major causes of the early morbidity in Allo-HSCT. To reduce graft failure and GVHD, we treated fifteen patients with SAA using high- dose of HSCT with both G-CSF mobilized PB and BMSCs from HLA-identical siblings to treat patients with SAA. All patients had successful bone marrow engraftment. Only one patient had late rejection. Median time to ANC greater than 0.5 × 10(9)/L and platelet counts greater than 20 × 10(9)/L was 12 and 16.5 days, respectively. No acute GVHD was observed. The incidence of chronic GVHD was 6.67%. The total three-year probability of disease-free survival was 79.8%. HSCT with both G-CSF mobilized PB and BMSCs is a promising approach for heavily transfused and/or allo-immunized patients with SAA.