Details

Autor(en) / Beteiligte

• Stachowska, Ewa
• Maciejewska-Markiewicz, Dominika
• Palma, Joanna
• Mielko, Karolina Anna
• Qasem, Badr
• Kozłowska-Petriczko, Katarzyna
• Ufnal, Marcin
• Sokolowska, Katarzyna Ewa
• Hawryłkowicz, Victoria
• Załęska, Patrycja
• Jakubczyk, Karolina
• Wunsch, Ewa
• Ryterska, Karina
• Skonieczna-Żydecka, Karolina
• Młynarz, Piotr

Titel

Precision Nutrition in NAFLD: Effects of a High-Fiber Intervention on the Serum Metabolome of NAFD Patients-A Pilot Study

Ist Teil von

• Nutrients, 2022-12, Vol.14 (24), p.5355

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Non-alcoholic fatty liver disease (NAFLD) is associated with dysfunction of the intestinal microbiota and its metabolites. We aimed to assess whether replacing bread with high-fiber buns beneficially changes the metabolome in NAFLD patients. This study involved 27 adult patients with NAFLD validated by FibroScan (CAP ≥ 234 dB/m). Patients were asked to replace their existing bread for two meals with high-fiber buns. In this way, the patients ate two rolls every day for 2 months. The following parameters were analysed (at the beginning and after 2 months): the anthropometric data (BIA), eating habits (24 h food recalls), gut barrier markers (lipopolysaccharide S and liposaccharide binding protein (LPS, LBP)), serum short-chain fatty acids (SCFAs) and branched chain fatty acids (BCFAs) by GC/MS chromatography, as well as serum metabolites (by H NMR spectroscopy). After 2 months of high-fiber roll consumption, the reduction of liver steatosis was observed (change Fibroscan CAP values from 309-277 dB/m). In serum propionate, acetate, isovaleric, and 2-methylbutyric decrease was observed. Proline, choline and one unknown molecule had higher relative concentration in serum at endpoint. A fiber-targeted dietary approach may be helpful in the treatment of patients with NAFLD, by changing the serum microbiota metabolome.