Details

Autor(en) / Beteiligte

• Harada, Kazuto
• Rogers, Jane E
• Iwatsuki, Masaaki
• Yamashita, Kohei
• Baba, Hideo
• Ajani, Jaffer A

Titel

Recent advances in treating oesophageal cancer [version 1; peer review: awaiting peer review]

Ist Teil von

• F1000 research, 2020, Vol.9, p.1189

Ort / Verlag

England: Faculty of 1000 Ltd

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Esophageal cancer (EC) is an aggressive malignancy with an increasing incidence and a poor prognosis. EC is histologically divided into two major categories: adenocarcinoma (EAC) and squamous cell carcinoma (ESCC). EAC and ESCC are molecularly different and therefore treatments should reflect the respective histological subtype. Combined modality therapy is needed for localized EC. When EC is advanced (stage 4), systemic therapy is the mainstay treatment for palliation. For localized EC, several strategies are considered standard, and more trials are necessary to determine a unified and more effective approach. The management for advanced EC is slowly evolving as immunotherapy is showing some promise for ESCC, but more data from ongoing studies are anticipated. Treatment advances will be based on high-definition genomic investigation of individual tumors. Herein, we review the contemporary trends in diagnosing and treating EAC and ESCC.