Details

Autor(en) / Beteiligte

• Visconti, Alessia
• Le Roy, Caroline I
• Rosa, Fabio
• Rossi, Niccolò
• Martin, Tiphaine C
• Mohney, Robert P
• Li, Weizhong
• de Rinaldis, Emanuele
• Bell, Jordana T
• Venter, J Craig
• Nelson, Karen E
• Spector, Tim D
• Falchi, Mario

Titel

Interplay between the human gut microbiome and host metabolism

Ist Teil von

• Nature communications, 2019-10, Vol.10 (1), p.4505-10, Article 4505

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The human gut is inhabited by a complex and metabolically active microbial ecosystem. While many studies focused on the effect of individual microbial taxa on human health, their overall metabolic potential has been under-explored. Using whole-metagenome shotgun sequencing data in 1,004 twins, we first observed that unrelated subjects share, on average, almost double the number of metabolic pathways (82%) than species (43%). Then, using 673 blood and 713 faecal metabolites, we found metabolic pathways to be associated with 34% of blood and 95% of faecal metabolites, with over 18,000 significant associations, while species showed less than 3,000 associations. Finally, we estimated that the microbiome was involved in a dialogue between 71% of faecal, and 15% of blood, metabolites. This study underlines the importance of studying the microbial metabolic potential rather than focusing purely on taxonomy to find therapeutic and diagnostic targets, and provides a unique resource describing the interplay between the microbiome and the systemic and faecal metabolic environments.