Details

Autor(en) / Beteiligte

• Jagadeesha, Gullahalli S.
• Mantelingu, Kempegowda
• Thimmegowda, Naraganahalli R.
• Rangappa, Kanchugarakoppal S.

Titel

Microwave-Assisted, Metal-Free, Chemoselective N-Formylation of Amines using 2-Formyl-1,3-dimethyl-1H-imidazol-3-ium Iodide and In Situ Synthesis of Benzimidazole and Isocyanides

Ist Teil von

• SynOpen (2017), 2022-06, Vol.6 (2), p.132-140

Ort / Verlag

Rüdigerstraße 14, 70469 Stuttgart, Germany: Georg Thieme Verlag KG

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Abstract An efficient, environmentally benign, chemoselective, microwave-assisted N -formylation protocol of aromatic, aliphatic, alicyclic, benzylic amines, inactivated aromatic amines and sterically demanding heterocyclic amines using 2-formyl-1,3-dimethyl-1 H -imidazol-3-ium iodide has been developed. This affords a series of N -substituted formamides with good to excellent yields (23 examples, 53–96% yield) and can be readily scaled. The methodology can be further extended to synthesize benzimidazole and isocyanide derivatives.