Details

Autor(en) / Beteiligte

• Yue, Grace Gar-Lee
• Kwok, Hin-Fai
• Lee, Julia Kin-Ming
• Jiang, Lei
• Chan, Kar-Man
• Cheng, Ling
• Wong, Eric Chun-Wai
• Leung, Ping-Chung
• Fung, Kwok-Pui
• Lau, Clara Bik-San

Titel

Novel anti-angiogenic effects of aromatic-turmerone, essential oil isolated from spice turmeric

Ist Teil von

• Journal of functional foods, 2015-05, Vol.15, p.243-253

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2015

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •In vitro anti-angiogenic activities of aromatic-turmerone in human endothelial cells.•In vivo anti-angiogenic activities of aromatic-turmerone in zebrafish embryos and matrigel plug mouse model.•This is possibly the first report on the anti-angiogenic activities of aromatic-turmerone.•Provided scientific insight into the development of such a component of turmeric essential oil to be an anti-angiogenic agent. Angiogenesis is essential for tumor growth and there is a continuing need for exploring new anti-angiogenic agents from natural products including herbs. Aromatic (Ar)-turmerone isolated from the rhizome of Curcuma longa Linn. (Turmeric) exhibits anti-tumor and immunomodulatory activities. In this study, the anti-angiogenic effects of Ar-turmerone were evaluated in human microvascular endothelial cells, zebrafish and Matrigel plugs mouse models. The data obtained indicate that Ar-turmerone treatment significantly inhibits the proliferation, tube formation and motility of HMEC-1 cells at non-cytotoxic concentrations (4.6–9.2 µM, p < 0.05). The mRNA expressions of metalloproteinase-2 and -9 as well as adhesion molecules could be down-regulated by Ar-turmerone at 18.4 µM (p < 0.05). In zebrafish model, the new blood vessel growth in embryos was significantly blocked by Ar-turmerone treatment (12.5–25 µg/mL medium). The bFGF-induced blood vessel formation in Matrigel plugs in C57BL/6 mice was suppressed by Ar-turmerone (25–50 µg/mL Matrigel). Thus, the in vitro and in vivo anti-angiogenic activities of Ar-turmerone were demonstrated for the first time. The findings suggest that such a component of turmeric essential oil has the potential to be further developed as an anti-angiogenic agent.