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Details

Autor(en) / Beteiligte
Titel
Cellular Immunotherapy Targeting Cancer Stem Cells: Preclinical Evidence and Clinical Perspective
Ist Teil von
  • Cells (Basel, Switzerland), 2021-03, Vol.10 (3), p.543
Ort / Verlag
Switzerland: MDPI
Erscheinungsjahr
2021
Quelle
EZB Free E-Journals
Beschreibungen/Notizen
  • The term "cancer stem cells" (CSCs) commonly refers to a subset of tumor cells endowed with stemness features, potentially involved in chemo-resistance and disease relapses. CSCs may present peculiar immunogenic features influencing their homeostasis within the tumor microenvironment. The susceptibility of CSCs to recognition and targeting by the immune system is a relevant issue and matter of investigation, especially considering the multiple emerging immunotherapy strategies. Adoptive cellular immunotherapies, especially those strategies encompassing the genetic redirection with chimeric antigen receptors (CAR), hold relevant promise in several tumor settings and might in theory provide opportunities for selective elimination of CSC subsets. Initial dedicated preclinical studies are supporting the potential targeting of CSCs by cellular immunotherapies, indirect evidence from clinical studies may be derived and new studies are ongoing. Here we review the main issues related to the putative immunogenicity of CSCs, focusing on and highlighting the existing evidence and opportunities for cellular immunotherapy approaches with T and non-T antitumor lymphocytes.
Sprache
Englisch
Identifikatoren
ISSN: 2073-4409
eISSN: 2073-4409
DOI: 10.3390/cells10030543
Titel-ID: cdi_doaj_primary_oai_doaj_org_article_6bc934d746e449b793e22ccc74b35891

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