Details

Autor(en) / Beteiligte

• Druge, Stéphanie
• Ruiz, Stéphanie
• Vardon-Bounes, Fanny
• Grare, Marion
• Labaste, François
• Seguin, Thierry
• Fourcade, Olivier
• Minville, Vincent
• Conil, Jean-Marie
• Georges, Bernard

Titel

Risk factors and the resistance mechanisms involved in Pseudomonas aeruginosa mutation in critically ill patients

Ist Teil von

• Journal of intensive care, 2019-07, Vol.7 (1), p.36-36, Article 36

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2019

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• The objective of this study was to determine the main risk factors of mutation as well as the mechanisms of acquired resistance. We conducted a 2-year prospective study in patients who were carriers of a strain and who had been admitted to a medical/surgical ICU. Of the 153 patients who were included, 34 had a mutation in their strain. In a multivariate analysis, a duration of ventilation > 24 days was a risk factor for mutation (risk ratio 4.29; CI 95% 1.94-9.49) while initial resistance was a protective factor (RR 0.36; CI 95% 0.18-0.71). In a univariate analysis, exposure of to ceftazidime was associated with an over-production of AmpC cephalosporinase and exposure to meropenem was associated with impermeability. A segmentation method based on the duration of ventilation (> 24 days), initial resistance, and exposure of strains to ceftazidime made it possible to predict at 83% the occurrence of mutation. The duration of ventilation and the presence of resistance as soon as is identified are predictive factors of mutation in ICU patients.