Details

Autor(en) / Beteiligte

• Alcaide, Maria L
• Nogueira, Nicholas F
• Salazar, Ana S
• Montgomerie, Emily K
• Rodriguez, Violeta J
• Raccamarich, Patricia D
• Barreto, Irma T
• McGaugh, Angela
• Sharkey, Mark E
• Mantero, Alejandro M
• Rodriguez, Allan E
• Beauchamps, Laura
• Jones, Deborah L

Titel

A Longitudinal Analysis of SARS-CoV-2 Antibody Responses Among People With HIV

Ist Teil von

• Frontiers in medicine, 2022-03, Vol.9, p.768138-768138

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2022

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The concentration and duration of antibodies (Ab) to SARS-CoV-2 infection predicts the severity of the disease and the clinical outcomes. Older people and those with HIV have impaired immune responses, worse outcomes after SARS-CoV-2 infection, and lower antibody responses after viral infection and vaccination. This study evaluated an Ab response to SARS-CoV-2 in people with HIV (PWH) and without HIV (HIV-) and its association with age. A total of 23 COVID+PWH and 21 COVID+HIV- participants were followed longitudinally for 6 months post-mild COVID-19. Immunoglobin G (IgG) and immunoglobin M (IgM) Ab responses were measured by an in-house developed ELISA. Time points and HIV status interaction were analyzed using Poisson generalized estimating equations, and correlations were analyzed using non-parametric tests. Median age in PWH was 55 years with 28.6% women, while in the HIV- group was 36 years with 60.9% women. The mean time from COVID-19 diagnosis to study enrollment was 16 days for PWH and 11 days for HIV-. The mean CD4+ T-cell count/μl for PWH was 772.10 (±365.21). SARS-CoV-2 IgM and IgG were detected at all time points and Ab response levels did not differ by HIV status ( > 0.05). At entry, age showed a weak direct association with IgG responses (ρ = 0.44, < 0.05) in HIV- but did not show any association in PWH. Similar associations between age, IgG, and HIV status emerged at day 14 (T1; ρ = 0.50, < 0.05), 3 months (T3; ρ = 0.50, < 0.05), and 6 months visit (T4; ρ = 0.78, < 0.05) in the HIV- group. The Ab responses in the 6-month post-SARS-CoV-2 infection did not differ by HIV status, though a positive association was found between age and Ab response in older PWH. Results suggest that immune protection and vaccine responses are similar for PWH than for those without HIV infection.