Neural regeneration research, 2015-06, Vol.10 (6), p.916-924
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Low-frequency transcranial magnetic stimulation is beneficial for enhancing synaptic plasticity in the aging brain
- Ist Teil von
- Neural regeneration research, 2015-06, Vol.10 (6), p.916-924
- Ort / Verlag
- India: Medknow Publications and Media Pvt. Ltd
- Erscheinungsjahr
- 2015
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- In the aging brain, cognitive function gradually dedines and causes a progressive reduction in the structural and functional plasticity of the hippocampus. Transcranial magnetic stimulation is an emerging and novel neurological and psychiatric tool used to investigate the neurobiology of cognitive function. Recent studies have demonstrated that low-frequency transcranial magnetic stimulation （〈1 Hz） ameliorates synaptic plasticity and spatial cognitive deficits in learning-impaired mice. However, the mechanisms by which this treatment improves these deficits during normal aging are still unknown. Therefore, the current study investigated the effects of transcranial magnetic stimulation on the brain-derived neurotrophic factor signal pathway, synaptic protein markers, and spatial memory behavior in the hippocampus of normal aged mice. The study also investigated the downstream regulator, Fyn kinase, and the downstream effectors, synaptophysin and growth-associated protein 43 （both synaptic markers）, to determine the possible mechanisms by which transcranial magnetic stimulation regulates cognitive capacity. Transcranial magnetic stimulation with low intensity （110% average resting motor threshold intensity, 1 Hz） increased mRNA and protein levels of brain-derived neurotrophic factor, tropomyosin receptor kinase B, and Fyn in the hippocampus of aged mice. The treatment also upregulated the mRNA and protein expression of synaptophysin and growth-associated protein 43 in the hippocampus of these mice. In conclusion, brain-derived neurotrophic factor signaling may play an important role in sustaining and regulating structural synaptic plasticity induced by transcranial magnetic stimulation in the hippocampus of aging mice, and Fyn may be critical during this regulation. These responses may change the structural plasticity of the aging hippocampus, thereby improving cognitive function.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1673-5374eISSN: 1876-7958DOI: 10.4103/1673-5374.158356Titel-ID: cdi_doaj_primary_oai_doaj_org_article_699d753711e84442a4704a1f31ff61ab
- Format
- –
- Schlagworte
- Aging, Aging (Biology), Animal cognition, axon, blood brain barrier, bone marrow mesenchymal stem cells, Brain, brain concussion, brain injury, Brain-derived neurotrophic factor, cell therapy, cellular therapy, cerebral ischemia, cognitive function, complications, diagnosis, dual diagnosis, Eg5, enhanced susceptibility-weighted angiography image, Experiments, ferumoxytol, hippocampus, human adipose-derived stem cells, intracerebral injection, kinesin-5, Laboratory animals, Magnetic brain stimulation, Magnetic fields, magnetic resonance imaging, Medical research, Memory, Methods, microtubule, middle cerebral artery occlusion, modified neurological severity scores, molecular motor protein, monastrol, MSCs, multiple sclerosis, myogenic differentiation, nanocarrier, nerve regeneration, neural regeneration, neurite outgrowth, neurodegenerative disorders, neuroimaging, neuromuscular junction (NMJ), Neuroplasticity, neuroprotection, neurotrophic factor, non-invasive brain stimulation, peptide library, phage display, Physiological aspects, post-concussion syndrome, Prussian blue staining, rats, regeneration, rehabilitation, Schwann cells, Signal transduction, spinal cord injuries, superparamagnetic iron oxide particles, tail vein injection, targeting, telomere shortening, TGF-β/BMP-7/Smad signaling, Transcranial magnetic stimulation, traumatic brain injury, Trf3, tumor suppression, 低频, 可塑性, 大脑, 突触素, 经颅磁刺激, 老年, 脑源性神经营养因子, 酪氨酸激酶受体