Nature communications, 2021-02, Vol.12 (1), p.897-897, Article 897
2021
Details
- Autor(en) / Beteiligte
- Titel
- Lasting antibody and T cell responses to SARS-CoV-2 in COVID-19 patients three months after infection
- Ist Teil von
- Nature communications, 2021-02, Vol.12 (1), p.897-897, Article 897
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The dynamics, duration, and nature of immunity produced during SARS-CoV-2 infection are still unclear. Here, we longitudinally measured virus-neutralising antibody, specific antibodies against the spike (S) protein, receptor-binding domain (RBD), and the nucleoprotein (N) of SARS-CoV-2, as well as T cell responses, in 25 SARS-CoV-2-infected patients up to 121 days post-symptom onset (PSO). All patients seroconvert for IgG against N, S, or RBD, as well as IgM against RBD, and produce neutralising antibodies (NAb) by 14 days PSO, with the peak levels attained by 15-30 days PSO. Anti-SARS-CoV-2 IgG and NAb remain detectable and relatively stable 3-4 months PSO, whereas IgM antibody rapidly decay. Approximately 65% of patients have detectable SARS-CoV-2-specific CD4 or CD8 T cell responses 3-4 months PSO. Our results thus provide critical evidence that IgG, NAb, and T cell responses persist in the majority of patients for at least 3-4 months after infection.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-021-21155-xTitel-ID: cdi_doaj_primary_oai_doaj_org_article_68c78fa7784c48cc8e87405a7f61c208
- Format
- –
- Schlagworte
- Adult, Antibodies, Antibodies, Neutralizing - blood, Antibodies, Neutralizing - immunology, Antibodies, Viral - immunology, CD4 antigen, CD4-Positive T-Lymphocytes - immunology, CD8 antigen, CD8-Positive T-Lymphocytes - immunology, Coronaviruses, COVID-19, COVID-19 - blood, COVID-19 - immunology, COVID-19 - virology, Female, Humans, Immunoglobulin G, Immunoglobulin G - blood, Immunoglobulin G - immunology, Immunoglobulin M, Immunoglobulin M - blood, Immunoglobulin M - immunology, Immunologic Memory, Infections, Interferon-gamma - metabolism, Kinetics, Leukocyte Common Antigens - metabolism, Lymphocytes, Lymphocytes T, Male, Middle Aged, Pandemics, Phenotype, Proteins, Receptors, CCR7 - metabolism, SARS-CoV-2 - physiology, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus 2, T-Lymphocytes - immunology, Viral diseases, Viruses