Details

Autor(en) / Beteiligte

• Shutkov, Ilya A
• Okulova, Yulia N
• Tyurin, Vladimir Yu
• Sokolova, Elena V
• Babkov, Denis A
• Spasov, Alexander A
• Gracheva, Yulia A
• Schmidt, Claudia
• Kirsanov, Kirill I
• Shtil, Alexander A
• Redkozubova, Olga M
• Shevtsova, Elena F
• Milaeva, Elena R
• Ott, Ingo
• Nazarov, Alexey A

Titel

Ru(III) Complexes with Lonidamine-Modified Ligands

Ist Teil von

• International journal of molecular sciences, 2021-12, Vol.22 (24), p.13468

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A series of bifunctional Ru(III) complexes with lonidamine-modified ligands (lonidamine is a selective inhibitor of aerobic glycolysis in cancer cells) was described. Redox properties of Ru(III) complexes were characterized by cyclic voltammetry. An easy reduction suggested a perspective for these agents as their whole mechanism of action seems to be based on activation by metal atom reduction. New compounds demonstrated a more pronounced antiproliferative potency than the parental drug; individual new agents were more cytotoxic than cisplatin. Stability studies showed an increase in the stability of complexes along with the linker length. A similar trend was noted for antiproliferative activity, cellular uptake, apoptosis induction, and thioredoxin reductase inhibition. Finally, at concentrations that did not alter water solubility, the selected new complex evoked no acute toxicity in Balb/c mice.