Details

Autor(en) / Beteiligte

• Bibi, Afshan
• Asif, Naveed
• Zujaja Hina Haroon
• Ijaz, Aamir
• Nawaz, Asif
• Qurat Ul Ain Atif

Titel

VITAMIN D DEFICIENCY PANDEMIC, A REALITY OR AN OVER DIAGNOSIS? NEED TO RETHINK VITAMIN D DEFICIENCY CUT OFF LEVELS

Ist Teil von

• Pakistan Armed Forces medical journal, 2020-10, Vol.70 (5), p.1327-1331

Ort / Verlag

Rawalpindi: AsiaNet Pakistan (Pvt) Ltd

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• ABSTRACT Objective: To determine clinical decision limits (cut off points) for vitamin D deficiency based on secondary hyperparathyroidism. Study Design: Cross sectional study. Place and Duration of Study: This study was conducted in the Department of Chemical Pathology and Endo-crinology, Armed Forces Institute of Pathology (AFIP), from Dec 2016 to May 2017. Methodology: One hundred and sixteen subjects, aged 18 to 60 years, of either gender, with vitamin D levels less than 50nmol/L, were consecutively included in the study. Results: Serum 25(OH) D had inverse relation with plasma iPTH level (r=-0.597, p<0.0001). Thirty five percent of the subjects with vitamin D level below 50nmol/L had secondary hyperparathyroidism. However, the frequency of secondary hyperparathyroidism was 52% in subjects with 25 (OH) D level less than 25nmol/L compared with 28% having serum vitamin D levels of 25-40nmol/L. None of the patient with Vitamin D level above 40nmol/L had secondary hyperparathyroidism. Receiver operating characteristic (ROC) curve showed that 25(OH) D level of 25.5nmol/L as an optimal cut off level for vitamin D deficiency based on Secondary Hyperparathyroidism with area under the curve (AUC) was 0.761. Conclusion: High frequency of secondary hyperparathyroidism in adults with vitamin D levels under 25nmol/L necessitates reconsideration of vitamin D cutoff limit for bone health.