Details

Autor(en) / Beteiligte

• An, Shengli
• Zhang, Peter
• Fang, Hong-Bin

Titel

Subgroup Identification in Survival Outcome Data Based on Concordance Probability Measurement

Ist Teil von

• Mathematics (Basel), 2023-06, Vol.11 (13), p.2855

Ort / Verlag

Basel: MDPI AG

Erscheinungsjahr

2023

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Identifying a subgroup of patients who may have an enhanced treatment effect in a randomized clinical trial has received increasing attention recently. For time-to-event outcomes, it is a challenge to define the effectiveness of a treatment and to choose a cutoff time point for identifying subgroup membership, especially in trials in which the two treatment arms do not differ in overall survival. In this paper, we propose a mixture cure model to identify a subgroup for a new treatment that was compared to a classical treatment (or placebo) in a randomized clinical trial with respect to survival time. Using the concordance probability measurement (K-index), we propose a statistic to test the existence of subgroups with effective treatments in the treatment arm. Subsequently, the subgroup is defined by a limited number of covariates based on the estimated area under the curve (AUC). The performance of this method in different scenarios is assessed through simulation studies. A real data example is also provided for illustration.