Details

Autor(en) / Beteiligte

• De-Luna-Gallardo, Daniel
• Cahuana-Quispe, Alberto
• García-Espinoza, Jaime
• Arámbula-Sánchez, Blanca
• Navarro-Delgadillo, Carlos
• Dávila-Díaz, Rodrigo
• Erazo-Franco, Mauricio
• Costa-Dulche, Alejandro
• Mena-Garza, Ana
• Morales-De-La-Cerda, Rodrigo
• Flores-Soto, David
• Cuervo-Vergara, Marco
• Reyes-Ibarra, Patricia
• Márquez-Esrpiella, Cuahutémoc

Titel

Use of cultivated epidermal allograft in chronic wounds: A novel therapeutic alternative

Ist Teil von

• Journal of cutaneous and aesthetic surgery, 2022-07, Vol.15 (3), p.237-243

Ort / Verlag

India: Wolters Kluwer India Pvt. Ltd

Erscheinungsjahr

2022

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Introduction: Chronic wounds represent a frequent cause of consultation for plastic and reconstructive surgeons. The use of epidermal culture stands out because they provide complete epithelialization, adequate aesthetic-functional results, and no morbidity for the patient. Epifast® is a pre-manufactured cultured epidermal allograft derived from the amplification in vitro of human keratinocytes. Materials and Methods: A prospective longitudinal multicenter study was carried out in four chronic wound reference centers, which were in charge of plastic and reconstructive surgery services. For a standardized wound bed preparation, the protocol synthesized by the acronym "TIME" was used. At the end of the "TIME" protocol, the pre-fabricated allograft was applied and removed 7 days after its application. Results: A total of 133 patients with diagnosis of chronic wound were included in the study. The median age was 69.3 ± 13.6 years. The most common comorbidity found was diabetes mellitus type 2 in 71.4% of the patients (n = 95) and systemic arterial hypertension in 60.2% of the patients (n = 80). The most frequent location of chronic wounds was seen in the lower extremity with 45.1% (n = 60). The mean duration for it to close was 46 ± 14 days, in which they closed within the first 3 months in 93% (n = 125) of the cases. About 91.7% (n = 122) of the wounds achieved total closure. Conclusion: Cultured epidermal allograft, combined with a meticulous technique and an adequate selection of patients, represents a safe and effective tool for chronic wounds.