Details

Autor(en) / Beteiligte

• Boulware, David
• Shroufi, Amir
• Dlamini, Sipho
• Govender, Nelesh P.
• Karstaedt, Alan
• Motlekar, Zaaheera
• van Cutsem, Gilles
• Nel, Jeremy
• Ive, Prudence
• Venter, Michelle
• Reddy, Denasha
• Chiller, Tom
• Menezes, Colin
• Boyles, Tom
• Stacey, Sarah Lynn
• Harrison, Thomas S.
• Meintjes, Graeme
• Madua, Matamela C.
• Rabie, Helena
• Dawood, Halima
• Jarvis, Joseph
• Moosa, Mahomed-Yunus S.
• Tsitsi, Merika
• Wake, Rachel
• Mangena, Phetho
• Variava, Ebrahim
• Potgieter, Samantha
• Black, John
• Wilson, Douglas

Titel

Southern African HIV Clinicians Society guideline for the prevention, diagnosis and management of cryptococcal disease among HIV-infected persons : 2019 update

Ist Teil von

• Southern African journal of HIV medicine, 2019, Vol.20 (1), p.1-16

Ort / Verlag

South Africa: AOSIS

Erscheinungsjahr

2019

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Six years after the Southern African HIV Clinicians Society cryptococcal disease guideline was published in 2013, cryptococcal meningitis (CM) remains an important cause of mortality among antiretroviral treatment (ART)-naïve and ART-experienced HIV-seropositive adults in South Africa. Several important practice-changing developments led us to update the guideline to diagnose, prevent and manage this common fungal opportunistic infection. The World Health Organization (WHO) published a guideline for advanced HIV disease in 2017 and a guideline relevant to resource-limited settings for HIV-associated CM in 2018. Cryptococcal antigen (CrAg) screening and pre-emptive treatment reduced all-cause mortality among ambulatory participants in a randomised clinical trial in Zambia and Uganda. Following an evaluation of reflex versus provider-initiated screening, national reflex laboratory CrAg screening was implemented in South Africa in 2016.