Details

Autor(en) / Beteiligte

• Kato, Hisaya
• Maezawa, Yoshiro
• Ouchi, Yasuo
• Takayama, Naoya
• Sone, Masamitsu
• Sone, Kanako
• Takada-Watanabe, Aki
• Tsujimura, Kyoko
• Koshizaka, Masaya
• Nagasawa, Sayaka
• Saitoh, Hisako
• Ohtaka, Manami
• Nakanishi, Mahito
• Tahara, Hidetoshi
• Shimamoto, Akira
• Iwama, Atsushi
• Eto, Koji
• Yokote, Koutaro

Titel

Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome

Ist Teil von

• Stem cell research, 2021-05, Vol.53, p.102360-102360, Article 102360

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2021

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Adult progeria Werner syndrome (WS), a rare autosomal recessive disorder, is characterized by accelerated aging symptoms after puberty. The causative gene, WRN, is a member of the RecQ DNA helicase family and is predominantly involved in DNA replication, repair, and telomere maintenance. Here, we report the generation of iPS cells from a patient with WS and correction of the WRN gene by the CRISPR/Cas9-mediated method. These iPSC lines would be a valuable resource for deciphering the pathogenesis of WS.