Details

Autor(en) / Beteiligte

• Annona, Giovanni
• Ferran, José Luis
• De Luca, Pasquale
• Conte, Ivan
• Postlethwait, John H
• D'Aniello, Salvatore

Titel

Expression Pattern of nos1 in the Developing Nervous System of Ray-Finned Fish

Ist Teil von

• Genes, 2022-05, Vol.13 (5), p.918

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Fish have colonized nearly all aquatic niches, making them an invaluable resource to understand vertebrate adaptation and gene family evolution, including the evolution of complex neural networks and modulatory neurotransmitter pathways. Among ancient regulatory molecules, the gaseous messenger nitric oxide (NO) is involved in a wide range of biological processes. Because of its short half-life, the modulatory capability of NO is strictly related to the local activity of nitric oxide synthases (Nos), enzymes that synthesize NO from L-arginine, making the localization of mRNAs a reliable indirect proxy for the location of NO action domains, targets, and effectors. Within the diversified actinopterygian paralogs, (alias ) is ubiquitously present as a single copy gene across the gnathostome lineage, making it an ideal candidate for comparative studies. To investigate variations in the NO system across ray-finned fish phylogeny, we compared expression patterns during the development of two well-established experimental teleosts (zebrafish and medaka) with an early branching holostean (spotted gar), an important evolutionary bridge between teleosts and tetrapods. Data reported here highlight both conserved expression domains and species-specific territories, confirming the ancestry of this signaling system and expanding the number of biological processes implicated in NO activities.