Cells (Basel, Switzerland), 2023-07, Vol.12 (14), p.1888
2023
Details
- Autor(en) / Beteiligte
- Titel
- Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases
- Ist Teil von
- Cells (Basel, Switzerland), 2023-07, Vol.12 (14), p.1888
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2023
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The intestinal barrier is a precisely regulated semi-permeable physiological structure that absorbs nutrients and protects the internal environment from infiltration of pathological molecules and microorganisms. Bile acids are small molecules synthesized from cholesterol in the liver, secreted into the duodenum, and transformed to secondary or tertiary bile acids by the gut microbiota. Bile acids interact with bile acid receptors (BARs) or gut microbiota, which plays a key role in maintaining the homeostasis of the intestinal barrier. In this review, we summarize and discuss the recent studies on bile acid disorder associated with intestinal barrier dysfunction and related diseases. We focus on the roles of bile acids, BARs, and gut microbiota in triggering intestinal barrier dysfunction. Insights for the future prevention and treatment of intestinal barrier dysfunction and related diseases are provided.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2073-4409eISSN: 2073-4409DOI: 10.3390/cells12141888Titel-ID: cdi_doaj_primary_oai_doaj_org_article_6243617155264e009b007f9dfe6f121a
- Format
- –
- Schlagworte
- Acids, Bile, bile acid, bile acid receptor, Bile acids, Cholesterol, Colorectal diseases, Development and progression, Diet, Digestive system, Digestive tract, Duodenum, E coli, Gastrointestinal diseases, gut microbiota, Health aspects, Homeostasis, IBD, Immune system, Inflammation, Inflammatory bowel disease, intestinal barrier, Intestinal microflora, Intestinal mucosa, Intestine, Kinases, Metabolism, Metabolites, Microbiota, Permeability, Physiology, Protein expression, Proteins, Review, sepsis