Details

Autor(en) / Beteiligte

• Liang, Joshua G
• Su, Danmei
• Song, Tian-Zhang
• Zeng, Yilan
• Huang, Weijin
• Wu, Jinhua
• Xu, Rong
• Luo, Peiwen
• Yang, Xiaofang
• Zhang, Xiaodong
• Luo, Shuangru
• Liang, Ying
• Li, Xinglin
• Huang, Jiaju
• Wang, Qiang
• Huang, Xueqin
• Xu, Qingsong
• Luo, Mei
• Huang, Anliang
• Luo, Dongxia
• Zhao, Chenyan
• Yang, Fan
• Han, Jian-Bao
• Zheng, Yong-Tang
• Liang, Peng

Titel

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

Ist Teil von

• Nature communications, 2021-03, Vol.12 (1), p.1346-1346, Article 1346

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells. Here we describe S-Trimer, a native-like trimeric subunit vaccine candidate for COVID-19 based on Trimer-Tag technology. Immunization of S-Trimer with either AS03 (oil-in-water emulsion) or CpG 1018 (TLR9 agonist) plus alum adjuvants induced high-level of neutralizing antibodies and Th1-biased cellular immune responses in animal models. Moreover, rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls, based on clinical observations and reduction of viral loads in lungs. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.