Details

Autor(en) / Beteiligte

• Greer, Renee L
• Dong, Xiaoxi
• Moraes, Ana Carolina F
• Zielke, Ryszard A
• Fernandes, Gabriel R
• Peremyslova, Ekaterina
• Vasquez-Perez, Stephany
• Schoenborn, Alexi A
• Gomes, Everton P
• Pereira, Alexandre C
• Ferreira, Sandra R G
• Yao, Michael
• Fuss, Ivan J
• Strober, Warren
• Sikora, Aleksandra E
• Taylor, Gregory A
• Gulati, Ajay S
• Morgun, Andrey
• Shulzhenko, Natalia

Titel

Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism

Ist Teil von

• Nature communications, 2016-11, Vol.7 (1), p.13329-13329, Article 13329

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Cross-talk between the gut microbiota and the host immune system regulates host metabolism, and its dysregulation can cause metabolic disease. Here, we show that the gut microbe Akkermansia muciniphila can mediate negative effects of IFNγ on glucose tolerance. In IFNγ-deficient mice, A. muciniphila is significantly increased and restoration of IFNγ levels reduces A. muciniphila abundance. We further show that IFNγ-knockout mice whose microbiota does not contain A. muciniphila do not show improvement in glucose tolerance and adding back A. muciniphila promoted enhanced glucose tolerance. We go on to identify Irgm1 as an IFNγ-regulated gene in the mouse ileum that controls gut A. muciniphila levels. A. muciniphila is also linked to IFNγ-regulated gene expression in the intestine and glucose parameters in humans, suggesting that this trialogue between IFNγ, A. muciniphila and glucose tolerance might be an evolutionally conserved mechanism regulating metabolic health in mice and humans.