Details

Autor(en) / Beteiligte

• Kaur, Namrita
• Ruiz-Velasco, Andrea
• Raja, Rida
• Howell, Gareth
• Miller, Jessica M.
• Abouleisa, Riham R.E.
• Ou, Qinghui
• Mace, Kimberly
• Hille, Susanne S.
• Frey, Norbert
• Binder, Pablo
• Smith, Craig P.
• Fachim, Helene
• Soran, Handrean
• Swanton, Eileithyia
• Mohamed, Tamer M.A.
• Müller, Oliver J.
• Wang, Xin
• Chernoff, Jonathan
• Cartwright, Elizabeth J.
• Liu, Wei

Titel

Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy

Ist Teil von

• iScience, 2022-03, Vol.25 (3), p.103973-103973, Article 103973

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Myocardial inflammation contributes to cardiomyopathy in diabetic patients through incompletely defined underlying mechanisms. In both human and time-course experimental samples, diabetic hearts exhibited abnormal ER, with a maladaptive shift over time in rodents. Furthermore, as a cardiac ER dysfunction model, mice with cardiac-specific p21-activated kinase 2 (PAK2) deletion exhibited heightened myocardial inflammatory response in diabetes. Mechanistically, maladaptive ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) is a novel transcriptional regulator of cardiac high-mobility group box-1 (HMGB1). Cardiac stress-induced release of HMGB1 facilitates M1 macrophage polarization, aggravating myocardial inflammation. Therapeutically, sequestering the extracellular HMGB1 using glycyrrhizin conferred cardioprotection through its anti-inflammatory action. Our findings also indicated that an intact cardiac ER function and protective effects of the antidiabetic drug interdependently attenuated the cardiac inflammation-induced dysfunction. Collectively, we introduce an ER stress-mediated cardiomyocyte-macrophage link, altering the macrophage response, thereby providing insight into therapeutic prospects for diabetes-associated cardiac dysfunction. [Display omitted] •In response to metabolic stress, loss of cardiac PAK2 leads to maladaptive ER stress•Cardiac CHOP-upregulated HMGB1 promotes M1 macrophage polarization by paracrine action•Pharmacological inhibition of HMGB1 decelerates myocardial inflammation•Vildagliptin and remediated ER alleviate cardiac dysfunction in diabetes Cardiovascular medicine; Biological sciences; Immunology; Cell biology