Details

Autor(en) / Beteiligte

• Nakano, Miki
• Ayano, Masahiro
• Kushimoto, Kazuo
• Kawano, Shotaro
• Higashioka, Kazuhiko
• Inokuchi, Shoichiro
• Mitoma, Hiroki
• Kimoto, Yasutaka
• Akahoshi, Mitsuteru
• Ono, Nobuyuki
• Arinobu, Yojiro
• Akashi, Koichi
• Horiuchi, Takahiko
• Niiro, Hiroaki

Titel

Increased Proportion of CD226 + B Cells Is Associated With the Disease Activity and Prognosis of Systemic Lupus Erythematosus

Ist Teil von

• Frontiers in immunology, 2021-07, Vol.12, p.713225-713225

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2021

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• CD226, an activating receptor expressed on the surface of natural killer (NK) cells and T cells, is also seen on B cells and CD226 polymorphism is associated with systemic lupus erythematosus (SLE). Because the specific roles of CD226 B cells in SLE are still unknown, we investigated the association of CD226 B cells with SLE. We measured CD226 expression on B cells and its subsets using flow cytometry in 48 SLE patients and 24 healthy controls (HCs). We assessed the relationships between CD226 B cells and SLE Disease Activity Index 2000 (SLEDAI-2K), clinical manifestations, laboratory data, and prognosis after 12 months. The proportions of CD226 cells in whole B cells and all its subsets were significantly higher in SLE patients than HCs. In SLE patients, the proportions of CD226 B cells and CD226 switched-memory (SM) B cells were significantly correlated with SLEDAI-2K scores and anti-dsDNA antibody titers, and negatively correlated with serum complement levels. Moreover, basal percentages of CD226 B cells and CD226 SM B cells were low in patients who were in Lupus Low Disease Activity State after 12 months. In patients with renal involvement, the proportion of CD226 B cells increased. Additionally, the proportion of CD226 B cells was higher in patients who were not in complete renal remission after 12 months. Increased proportion of CD226 B cells was associated with disease activity and prognosis of SLE. CD226 B cells may be a useful biomarker for the management of SLE.