Details

Autor(en) / Beteiligte

• Nakao, Yoichi
• Shiroiwa, Takeru
• Murayama, Shuhei
• Matsunaga, Shigeki
• Goto, Yasuyuki
• Matsumoto, Yoshitsugu
• Fusetani, Nobuhiro

Titel

Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp

Ist Teil von

• Marine drugs, 2004-06, Vol.2 (2), p.55-62

Ort / Verlag

Basel: MDPI AG

Erscheinungsjahr

2004

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 μg/mL.