Details

Autor(en) / Beteiligte

• DuBois, Jonathan M.
• Mathotaarachchi, Sulantha
• Rousset, Olivier G.
• Sziklas, Viviane
• Sepulcre, Jorge
• Guiot, Marie-Christine
• Hall, Jeffery A.
• Massarweh, Gassan
• Soucy, Jean-Paul
• Rosa-Neto, Pedro
• Kobayashi, Eliane

Titel

Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia

Ist Teil von

• NeuroImage clinical, 2021-01, Vol.29, p.102552-102552, Article 102552

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• •Utilized graph theory to study mGluR5 networks in FCD patients.•Global reductions were observed in mGluR5 network efficiency and resilience.•Epilepsy duration was associated with network efficiency in hub regions.•Focal epileptogenic lesions may progressively reduce whole brain network integration. To determine the extent of metabotropic glutamate receptor type 5 (mGluR5) network abnormalities associated with focal cortical dysplasia (FCD), we performed graph theoretical analysis of [11C]ABP688 PET binding potentials (BPND), which allows for quantification of mGluR5 availability. Undirected graphs were constructed for the entire cortex in 17 FCD patients and 33 healthy controls using inter-regional similarity of [11C]ABP688 BPND. We assessed group differences in network integration between healthy controls and the ipsilateral and contralateral hemispheres of FCD patients. Compared to healthy controls, FCD patients showed reduced network efficiency and reduced small-world connectivity. The mGluR5 network of FCD patients was also less resilient to targeted removal of high centrality nodes, suggesting a less integrated network organization. In highly efficient hub nodes of FCD patients, we observed a significant negative correlation between local efficiency and duration of epilepsy only in the contralateral hemisphere, suggesting that some nodes may be more vulnerable to persistent epileptic activity. Our study provides the first in vivo evidence for a widespread reduction in cortical mGluR5 network integration in FCD patients. In addition, we find that ongoing epileptic activity may alter chemoarchitectural brain organization resulting in reduced efficiency in distant regions that are essential for network integration.