Details

Autor(en) / Beteiligte

• Silva, Jéssica D
• Marques, Joana
• Santos, Inês P
• Batista de Carvalho, Ana L M
• Martins, Clara B
• Laginha, Raquel C
• Batista de Carvalho, Luís A E
• Marques, Maria Paula M

Titel

A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line

Ist Teil von

• Molecules (Basel, Switzerland), 2023-02, Vol.28 (4), p.1698

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A dinuclear Pt(II) complex with putrescine as bridging polyamine ligand ([Pt Put (NH ) ]Cl ) was synthesized and assessed as to its potential anticancer activity against a human non-small cell lung cancer line (A549), as well as towards non-cancer cells (BEAS-2B). This effect was evaluated through in vitro cytotoxicity assays (MTT and SRB) coupled to microFTIR and microRaman spectroscopies, the former delivering information on growth-inhibiting and cytotoxic abilities while the latter provided very specific information on the metabolic impact of the metal agent (at the sub-cellular level). Regarding cancer cells, a major impact of [Pt Put (NH ) ]Cl was evidenced on cellular proteins and lipids, as compared to DNA, particularly via the Amide I and Amide II signals. The effect of the chelate on non-malignant cells was lower than on malignant ones, evidencing a promising low toxicity towards healthy cells.