Details

Autor(en) / Beteiligte

• Kojima, Kenji K

Titel

AcademH , a lineage of Academ DNA transposons encoding helicase found in animals and fungi

Ist Teil von

• Mobile DNA, 2020-04, Vol.11 (1), p.15-15, Article 15

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• DNA transposons are ubiquitous components of eukaryotic genomes. superfamily of DNA transposons is one of the least characterized DNA transposon superfamilies in eukaryotes. DNA transposons belonging to the superfamily have been reported from various animals, one red algal species , and one fungal species . Six families from encode a helicase in addition to putative transposase, while some other families encode a single protein which contains a putative transposase and an XPG nuclease. Systematic searches on Repbase and BLAST searches against publicly available genome sequences revealed that several species of fungi and animals contain multiple transposon families encoding a helicase. These families generate 9 or 10-bp target site duplications (TSDs) while families lacking helicase generate 3 or 4-bp TSDs. Phylogenetic analysis clearly shows two lineages inside of , designated here as and for encoding helicase or XPG nuclease, respectively. One sublineage of in animals encodes plant homeodomain (PHD) finger in its transposase, and its remnants are found in several fish genomes. The lineage of TEs is widely distributed in animals and fungi, and originated early in the evolution of DNA transposons. This analysis highlights the structural diversity in one less studied superfamily of eukaryotic DNA transposons.