Details
- Autor(en) / Beteiligte
- Titel
- A Unique SARS-CoV-2 Spike Protein P681H Variant Detected in Israel
- Ist Teil von
- Vaccines (Basel), 2021-06, Vol.9 (6), p.616
- Ort / Verlag
- Basel: MDPI AG
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- The routine detection, surveillance, and reporting of novel SARS-CoV-2 variants is crucial, as these threaten to hinder global vaccination efforts. Herein we report a novel local variant with a non-synonymous mutation in the spike (S) protein P681H. This local Israeli variant was not associated with a higher infection rate or higher prevalence. Furthermore, the local variant was successfully neutralized by sera from fully vaccinated individuals at a comparable level to the B.1.1.7 variant and an Israel wild-type strain. While it is not a variant of concern, routine monitoring by sequencing is still required.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2076-393XeISSN: 2076-393XDOI: 10.3390/vaccines9060616Titel-ID: cdi_doaj_primary_oai_doaj_org_article_5d7913bb58e9467bbb3a4fe7caafa984
- Format
- –
- Schlagworte
- Bioinformatics, Brief Report, Coronaviruses, Covid-19, Genomes, Infections, Mutation, Phylogenetics, Proteins, Quality control, SARS-CoV-2, sequencing, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus 2, Spike protein, Surveillance, Testing laboratories, Vaccination, variant of concern, virus neutralization, Viruses