Toxins, 2022-07, Vol.14 (8), p.526
2022
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- Autor(en) / Beteiligte
- Titel
- Serum Trimethylamine N-Oxide Level Is Associated with Peripheral Arterial Stiffness in Advanced Non-Dialysis Chronic Kidney Disease Patients
- Ist Teil von
- Toxins, 2022-07, Vol.14 (8), p.526
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2022
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Trimethylamine N-oxide (TMAO) is a gut-derived uremic toxin involved in cardiovascular diseases (CVD). Peripheral arterial stiffness (PAS), measured by the brachial-ankle pulse wave velocity (baPWV) is a valuable indicator of the existence of CVD alongside other diseases. The study recruited 157 patients with chronic kidney disease (CKD) stages 3 to 5, and aimed to determine the correlation between serum TMAO and PAS, defined as a baPWV of >18.0 m/s. Patients with CKD who were diagnosed with PAS (68 patients, 43.3%) were older, had a higher percentage of hypertension or diabetes mellitus, higher systolic blood pressure, and higher fasting glucose, C-reactive protein, and TMAO levels. Furthermore, besides old age and SBP, patients with CKD who had higher serum TMAO were more likely to have PAS, with an odds ratio of 1.016 (95% confidence interval = 1.002−1.029, p = 0.021) by multivariate logistic regression analysis. Correlation analysis demonstrated that serum TMAO was positively correlated with C-reactive protein level and either left or right baPWV. Thus, we supposed that serum TMAO levels were associated with PAS in patients with advanced non-dialysis CKD.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2072-6651eISSN: 2072-6651DOI: 10.3390/toxins14080526Titel-ID: cdi_doaj_primary_oai_doaj_org_article_5d23d7810e724bc88a28fb1803241ed2
- Format
- –
- Schlagworte
- Age, Aging, Ankle, Ankle Brachial Index, Blood pressure, brachial-ankle pulse wave velocity, C-Reactive Protein, Cardiovascular Diseases, chronic kidney disease, Chronic kidney failure, Collagen, Complications and side effects, Correlation analysis, Cytokines, Diabetes mellitus, Dialysis, Hemodialysis, Humans, Hypertension, Inflammation, Kidney diseases, Kidneys, Metabolism, Metabolites, Methylamines, Microbiota, Mortality, Oxidative stress, peripheral artery stiffness, Peripheral vascular diseases, Population, Proteins, Pulse Wave Analysis, Regression analysis, Renal Insufficiency, Chronic, Risk Factors, Smooth muscle, Statistical analysis, Stiffness, Toxins, Trimethylamine, trimethylamine N-oxide, Vascular Stiffness, Wave velocity