Vaccines (Basel), 2021-04, Vol.9 (4), p.354
2021
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Details
- Autor(en) / Beteiligte
- Titel
- Recent Advances in PRRS Virus Receptors and the Targeting of Receptor-Ligand for Control
- Ist Teil von
- Vaccines (Basel), 2021-04, Vol.9 (4), p.354
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2021
- Quelle
- Elektronische Zeitschriftenbibliothek (Open access)
- Beschreibungen/Notizen
- Cellular receptors play a critical role in viral infection. At least seven cellular molecules have been identified as putative viral entry mediators for porcine reproductive and respiratory syndrome virus (PRRSV). Accumulating data indicate that among these candidates, CD163, a cysteine-rich scavenger receptor on macrophages, is the major receptor for PRRSV. This review discusses the recent advances and understanding of the entry of PRRSV into cells, viral pathogenesis in CD163 gene-edited swine, and CD163 as a potential target of receptor-ligand for the control of PRRS.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2076-393XeISSN: 2076-393XDOI: 10.3390/vaccines9040354Titel-ID: cdi_doaj_primary_oai_doaj_org_article_5d1dfe9d94b7429591aea9f33a697b91
- Format
- –
- Schlagworte
- Animal diseases, Antibodies, CD163, CD163 antigen, Gene expression, Genetic modification, Genomes, Heparan sulfate, Hogs, Immunoglobulins, Infections, Ligands, Macrophages, Pathogenesis, porcine reproductive and respiratory syndrome, Proteins, PRRSV, receptor, Receptors, Review, Scavenger receptors, Taxonomy, Viral diseases, Viral infections, Viruses