Details

Autor(en) / Beteiligte

• Horsley, Jonathan J.
• Schroeder, Gabrielle M.
• Thomas, Rhys H.
• de Tisi, Jane
• Vos, Sjoerd B.
• Winston, Gavin P.
• Duncan, John S.
• Wang, Yujiang
• Taylor, Peter N.

Titel

Volumetric and structural connectivity abnormalities co-localise in TLE

Ist Teil von

• NeuroImage clinical, 2022-01, Vol.35, p.103105, Article 103105

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• •Structural connectivity abnormalities present in TLE.•Grey matter volume abnormalities also present in TLE.•96 controls & 144 patients to investigate abnormality co-localisation.•Abnormalities co-localise in individuals, and at group level.•More abnormalities related to longer epilepsy duration. Patients with temporal lobe epilepsy (TLE) exhibit both volumetric and structural connectivity abnormalities relative to healthy controls. How these abnormalities inter-relate and their mechanisms are unclear. We computed grey matter volumetric changes and white matter structural connectivity abnormalities in 144 patients with unilateral TLE and 96 healthy controls. Regional volumes were calculated using T1-weighted MRI, while structural connectivity was derived using white matter fibre tractography from diffusion-weighted MRI. For each regional volume and each connection strength, we calculated the effect size between patient and control groups in a group-level analysis. We then applied hierarchical regression to investigate the relationship between volumetric and structural connectivity abnormalities in individuals. Additionally, we quantified whether abnormalities co-localised within individual patients by computing Dice similarity scores. In TLE, white matter connectivity abnormalities were greater when joining two grey matter regions with abnormal volumes. Similarly, grey matter volumetric abnormalities were greater when joined by abnormal white matter connections. The extent of volumetric and connectivity abnormalities related to epilepsy duration, but co-localisation did not. Co-localisation was primarily driven by neighbouring abnormalities in the ipsilateral hemisphere. Overall, volumetric and structural connectivity abnormalities were related in TLE. Our results suggest that shared mechanisms may underlie changes in both volume and connectivity alterations in patients with TLE.