Details

Autor(en) / Beteiligte

• Andrade, Diocesio Alves Pinto
• Paulino, Eduardo
• Buzatto, Isabela Panzeri Carlotti
• Wada, Danilo Tadao
• Andrade, Warne Pedro
• Melo, Andreia Cristina
• Nogueira-Rodrigues, Angelica

Titel

Uterine carcinosarcoma with microsatellite instability - does immunotherapy modify the therapeutic scenario? A case report and literature review

Ist Teil von

• Brazilian Journal of Oncology, 2023-09, Vol.19

Ort / Verlag

Sociedade Brasileira de Oncologia Clínica, Sociedade Brasileira de Cirurgia Clínica and Sociedade Brasileira de Radioterapia

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Carcinosarcomas were reclassified by World Health Organization as high-grade uterine carcinomas in 2014. Due to its rare histology, comprising only 5% of uterine carcinomas, there is a small representation of this tumor in studies that evaluate metastatic uterine carcinomas treatment. In 2022, the treatment of metastatic uterine carcinomas has changed dramatically with the inclusion of immunotherapy in the therapeutic arsenal, either as a monotherapy or in combination with lenvatinib. The status of microsatellites is paramount in the therapeutic decision for this tumor; carcinosarcoma patients haven't been included in randomized trials so far. Here we report the case of a 60-year-old woman diagnosed with recurrent carcinosarcoma metastatic to the liver and pelvis. Immunohistochemistry demonstrated microsatellite instability (loss of MLH1 and PMS2 nuclear staining). She received immunotherapy with pembrolizumab every three weeks as monotherapy and after 4 cycles, she achieved a complete radiological response in the liver and a partial response in the pelvis.