International journal of molecular sciences, 2021-04, Vol.22 (7), p.3767
2021
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- Autor(en) / Beteiligte
- Titel
- Characterization of Type I Interferon-Associated Chemokines and Cytokines in Lacrimal Glands of Nonobese Diabetic Mice
- Ist Teil von
- International journal of molecular sciences, 2021-04, Vol.22 (7), p.3767
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Type I interferons (IFNs) are required for spontaneous lacrimal gland inflammation in the nonobese diabetic (NOD) mouse model of Sjögren's disease, but the consequences of type I IFN signaling are not well-defined. Here, we use RNA sequencing to define cytokine and chemokine genes upregulated in lacrimal glands of NOD mice in a type I IFN-dependent manner. Interleukin (IL)-21 was the highest differentially expressed cytokine gene, and knockout NOD mice were relatively protected from lacrimal gland inflammation. We defined a set of chemokines upregulated early in disease including and , which share a receptor, CXCR3. CXCR3 T cells were enriched in lacrimal glands with a dominant proportion of CXCR3 regulatory T cells. Together these data define the early cytokine and chemokine signals associated with type I IFN-signaling in the development of lacrimal gland inflammation in NOD mice providing insight into the role of type I IFN in autoimmunity development.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms22073767Titel-ID: cdi_doaj_primary_oai_doaj_org_article_5a578f7948f946c8925b9d8c9d66680c
- Format
- –
- Schlagworte
- Animals, Autoimmunity, Chemokine CXCL10 - genetics, Chemokine CXCL10 - immunology, Chemokine CXCL9 - genetics, Chemokine CXCL9 - immunology, Chemokines, CXCL10 protein, CXCR3 protein, Cytokines, Diabetes, Diabetes mellitus, Disease, Exocrine glands, Gene expression, Immunoregulation, Inflammation, Inflammation - genetics, Inflammation - immunology, Inflammation - pathology, Interferon, Interleukin 21, Interleukins - genetics, Interleukins - immunology, Lacrimal Apparatus - immunology, Lacrimal Apparatus - pathology, Lacrimal gland, Lymphocytes, Lymphocytes T, Males, Mice, Mice, Inbred NOD, Mice, Knockout, nonobese diabetic mice, Pathogenesis, Receptors, CXCR3 - genetics, Receptors, CXCR3 - immunology, Rodents, Signal Transduction - genetics, Signal Transduction - immunology, Sjogren's syndrome, Sjögren’s disease, T-Lymphocytes, Regulatory - immunology, T-Lymphocytes, Regulatory - pathology, type I interferon