Details

Autor(en) / Beteiligte

• Kim, In Hye
• Jeon, Yong Hwan
• Lee, Tae-Kyeong
• Cho, Jeong Hwi
• Lee, Jae-Chul
• Park, Joon Ha
• Ahn, Ji Hyeon
• Shin, Bich-Na
• Kim, Yang Hee
• Hong, Seongkweon
• Yan, Bing Chun
• Won, Moo-Ho
• Lee, Yun Lyul

Titel

Neuroprotective effects of ischemic preconditioning on hippocampal CA1 pyramidal neurons through maintaining calbindin D28k immunoreactivity following subsequent transient cerebral ischemia

Ist Teil von

• Neural regeneration research, 2017-06, Vol.12 (6), p.918-924

Ort / Verlag

India: Medknow Publications and Media Pvt. Ltd

Erscheinungsjahr

2017

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Ischemic preconditioning elicited by a non-fatal brief occlusion of blood flow has been applied for an experimental therapeutic strategy against a subsequent fatal ischemic insult. In this study, we investigated the neuroprotective effects of ischemic preconditioning（2-minute transient cerebral ischemia） on calbindin D28k immunoreactivity in the gerbil hippocampal CA1 area following a subsequent fatal transient ischemic insult（5-minute transient cerebral ischemia）. A large number of pyramidal neurons in the hippocampal CA1 area died 4 days after 5-minute transient cerebral ischemia. Ischemic preconditioning reduced the death of pyramidal neurons in the hippocampal CA1 area. Calbindin D28k immunoreactivity was greatly attenuated at 2 days after 5-minute transient cerebral ischemia and it was hardly detected at 5 days post-ischemia. Ischemic preconditioning maintained calbindin D28 k immunoreactivity after transient cerebral ischemia. These findings suggest that ischemic preconditioning can attenuate transient cerebral ischemia-caused damage to the pyramidal neurons in the hippocampal CA1 area through maintaining calbindin D28k immunoreactivity.