Details

Autor(en) / Beteiligte

• Sutton, S. Scott
• Magagnoli, Joseph
• Cummings, Tammy H.
• Hardin, James W.

Titel

Odds of Acute Kidney Injury in Patients Receiving Dipeptidyl Peptidase 4 Inhibitors: A National Cohort Study Within the Department of Veterans Affairs

Ist Teil von

• Clinical and translational science, 2019-11, Vol.12 (6), p.698-703

Ort / Verlag

United States: John Wiley & Sons, Inc

Erscheinungsjahr

2019

Quelle

Wiley Online Library Journals

Beschreibungen/Notizen

• Preclinical and clinical data of dipeptidyl peptidase 4 (DPP‐4) inhibitors have demonstrated discordant data regarding acute kidney injury (AKI). Therefore, we aimed to evaluate the association between DPP‐4 use and AKI. This cohort study utilized data from the Department of Veterans Affairs evaluating patients diagnosed with type 2 (T2) diabetes with a DPP‐4 inhibitor and compared with nondiabetic and diabetic patients. The primary end point is the development of AKI, and statistical analyses were performed to examine the association. DPP‐4 use is associated with a lower odds of AKI compared with diabetics (adjusted odds ratio (OR) = 0.39; 95% confidence interval (CI) = 0.32–0.48) and nondiabetics (OR = 0.64; 95% CI = 0.52–0.79). DPP‐4 use in patients with T2 diabetes mellitus is associated with lower odds of AKI within 120 days compared with nondiabetic and diabetic controls when adjusting for study covariates.