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DBP rs7041 and DHCR7 rs3829251 are Linked to CD4 + Recovery in HIV Patients on Antiretroviral Therapy
Ist Teil von
Frontiers in pharmacology, 2022-01, Vol.12, p.773848-773848
Ort / Verlag
Switzerland: Frontiers Media S.A
Erscheinungsjahr
2022
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
The lack of the recovery of CD4
T-cells (CD4
recovery) among immunodeficiency virus (HIV)-infected patients on antiretroviral therapy (ART) is not well known. We aimed to analyze the association between single nucleotide polymorphisms (SNPs) underlying vitamin D metabolism and the CD4
recovery in naïve HIV-infected patients who started ART with low baseline CD4
.
We conducted a retrospective study in 411 naïve individuals with plasma HIV load >200 copies/mL and CD4
<200 cells/mm
. During 24 months of follow-up, all patients had plasma HIV load <50 copies/mL. DNA genotyping was performed using the Sequenom MassARRAY platform. The outcome variable was the change in CD4
during the study.
CD4
recovery was higher in patients carrying
rs7041 AA genotype (AA versus CC/AC) and
rs3829251 AA genotype (AA versus GG/AG) (
-value < 0.05).
rs7041 AA genotype was linked to increase in CD4
(adjusted arithmetic mean ratio (aAMR) = 1.22;
-value = 0.011), increase in CD4
≥P75th [adjusted odds ratio (aOR) = 2.31;
-value = 0.005], slope of CD4
recovery (aAMR = 1.25;
-value = 0.008), slope of CD4
recovery ≥ P75th (aOR = 2.55;
-value = 0.005) and achievement of CD4
≥500 cells/mm
(aOR = 1.89;
-value = 0.023). Besides,
rs3829251 AA genotype was related to increase in CD4
(aAMR = 1.43;
-value = 0.031), increase in CD4
≥P75th (aOR = 3.92;
-value = 0.030), slope of CD4
recovery (aAMR = 1.40;
-value = 0.036), slope of CD4
recovery ≥ P75th (aOR = 3.42;
-value = 0.031) and achievement of CD4
≥500 cells/mm
(aOR = 5.68;
-value = 0.015).
In summary,
rs3829251 and
rs7041 polymorphisms were associated with CD4
recovery in HIV-infected patients who started cART with low CD4
T-cell counts.