Details

Autor(en) / Beteiligte

• Eldaly, Zeiad H
• Maasoud, Ali A
• Saad, Mohamed S
• Mohamed, Abdelsalam A

Titel

Comparison between Ologen implant and different concentrations of Mitomycin C as an adjuvant to trabeculectomy surgery

Ist Teil von

• Oman journal of ophthalmology, 2017-09, Vol.10 (3), p.184-192

Ort / Verlag

India: Medknow Publications and Media Pvt. Ltd

Erscheinungsjahr

2017

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Trabeculectomy is the most common surgical procedure for treatment of glaucoma. To improve success rates, adjuvants were utilized as Mitomycin C (MMC) and Ologen implant. This study aims to establish efficacy and safety of Ologen implant versus MMC in trabeculectomy. A prospective, comparative clinical study was conducted at the Department of Ophthalmology, Assiut University, between December 2014 and April 2016. Patients with primary open-angle glaucoma (OAG), primary narrow-angle glaucoma and secondary OAG were assigned equally to trabeculectomy with Ologen, 0.4 mg/mL or 0.2 mg/mL MMC. The study outcome measures were reduction in intra-ocular pressure (IOP), success rates, survival analysis, and rate of complications. SPSS software Version 17.0 (SPSS, Inc., IL, USA) was utilized. Thirty eyes were included in the study. Mean baseline IOP in Ologen, MMC 0.4 and MMC 0.2 groups were 27.43 ± 2.97, 28.4 ± 3.24, and 27.56 ± 2.69 mmHg, respectively. At week 24 follow-up, mean IOP in Ologen, MMC 0.4 and MMC 0.2 groups were 18.55 ± 3.18, 16.2 ± 3.22, and 16.93 ± 3.04 mmHg, respectively. No significant inter-group difference was noticed at any visits. Complete success was achieved in 10%, 40%, and 30%, whereas incomplete success in 70%, 50%, and 60%, respectively in Ologen, MMC 0.4 and MMC 0.2 groups. No treatment group difference was reported by Kaplan-Meier analysis. Shallow anterior chamber occurred more in Ologen and MMC 0.4 groups. A single case of serous choroidal effusion had occurred in MMC 0.4 group. Ologen implant is a promising alternative to MMC for improving the success rate of trabeculectomy.