Details

Autor(en) / Beteiligte

• Bencze, János
• Mórotz, Gábor Miklós
• Seo, Woosung
• Bencs, Viktor
• Kálmán, János
• Miller, Christopher Charles John
• Hortobágyi, Tibor

Titel

Biological function of Lemur tyrosine kinase 2 (LMTK2): implications in neurodegeneration

Ist Teil von

• Molecular brain, 2018-04, Vol.11 (1), p.20-20, Article 20

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Neurodegenerative disorders are frequent, incurable diseases characterised by abnormal protein accumulation and progressive neuronal loss. Despite their growing prevalence, the underlying pathomechanism remains unclear. Lemur tyrosine kinase 2 (LMTK2) is a member of a transmembrane serine/threonine-protein kinase family. Although it was described more than a decade ago, our knowledge on LMTK2's biological functions is still insufficient. Recent evidence has suggested that LMTK2 is implicated in neurodegeneration. After reviewing the literature, we identified three LMTK2-mediated mechanisms which may contribute to neurodegenerative processes: disrupted axonal transport, tau hyperphosphorylation and enhanced apoptosis. Moreover, LMTK2 gene expression is decreased in an Alzheimer's disease mouse model. According to these features, LMTK2 might be a promising therapeutic target in near future. However, further investigations are required to clarify the exact biological functions of this unique protein.